Ontology highlight
ABSTRACT:
SUBMITTER: Hou X
PROVIDER: S-EPMC3695727 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Hou Xiaowei X Pedi Leanne L Diver Melinda M MM Long Stephen B SB
Science (New York, N.Y.) 20121122 6112
The plasma membrane protein Orai forms the pore of the calcium release-activated calcium (CRAC) channel and generates sustained cytosolic calcium signals when triggered by depletion of calcium from the endoplasmic reticulum. The crystal structure of Orai from Drosophila melanogaster, determined at 3.35 angstrom resolution, reveals that the calcium channel is composed of a hexameric assembly of Orai subunits arranged around a central ion pore. The pore traverses the membrane and extends into the ...[more]