Ontology highlight
ABSTRACT:
SUBMITTER: Dave RK
PROVIDER: S-EPMC3695918 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Dave Richa K RK Dinger Marcel E ME Andrew Megan M Askarian-Amiri Marjan M Hume David A DA Kellie Stuart S
PloS one 20130628 6
PTPRJ/CD148 is a tyrosine phosphatase that has tumour suppressor-like activity. Quantitative PCR of various cells and tissues revealed that it is preferentially expressed in macrophage-enriched tissues. Within lymphoid tissues immunohistochemistry revealed that PTPRJ/CD148 co-localised with F4/80, indicating that macrophages most strongly express the protein. Macrophages express the highest basal level of ptprj, and this is elevated further by treatment with LPS and other Toll-like receptor liga ...[more]