Ontology highlight
ABSTRACT:
SUBMITTER: Gleim S
PROVIDER: S-EPMC3696120 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Gleim Scott S Stitham Jeremiah J Tang Wai Ho WH Li Hong H Douville Karen K Chelikani Prashen P Rade Jeffrey J JJ Martin Kathleen A KA Hwa John J
PloS one 20130628 6
Thromboxane and its receptor have emerged as key players in modulating vascular thrombotic events. Thus, a dysfunctional hTP genetic variant may protect against (hypoactivity) or promote (hyperactivity) vascular events, based upon its activity on platelets. After extensive in silico analysis, six hTP-α variants were selected (C(68)S, V(80)E, E(94)V, A(160)T, V(176)E, and V(217)I) for detailed biochemical studies based on structural proximity to key regions involved in receptor function and in si ...[more]