Polymorphisms in 1-carbon metabolism, epigenetics and folate-related pathologies.
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ABSTRACT:
SUBMITTER: Stover PJ
PROVIDER: S-EPMC3696357 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Publications
Polymorphisms in 1-carbon metabolism, epigenetics and folate-related pathologies.
Journal of nutrigenetics and nutrigenomics 20110101 5
Folate-mediated 1-carbon metabolism is a network of interconnected metabolic pathways necessary for the synthesis of purine nucleotides, thymidylate and the remethylation of homocysteine to methionine. Disruptions in this pathway influence both DNA synthesis and stability and chromatin methylation, and result from nutritional deficiencies and common gene variants. The mechanisms underlying folate-associated pathologies and developmental anomalies have yet to be established. This review focuses o ...[more]
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