Ontology highlight
ABSTRACT:
SUBMITTER: Doncic A
PROVIDER: S-EPMC3696412 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Doncic Andreas A Skotheim Jan M JM
Molecular cell 20130516 6
Cellular transitions are important for all life. Such transitions, including cell fate decisions, often employ positive feedback regulation to establish and stabilize new cellular states. However, positive feedback is unlikely to underlie stable cell-cycle arrest in yeast exposed to mating pheromone because the signaling pathway is linear, rather than bistable, over a broad range of extracellular pheromone concentration. We show that the stability of the pheromone-arrested state results from coh ...[more]