Ontology highlight
ABSTRACT:
SUBMITTER: Myung JK
PROVIDER: S-EPMC3696543 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
The Journal of clinical investigation 20130603 7
Hormone therapies for advanced prostate cancer target the androgen receptor (AR) ligand-binding domain (LBD), but these ultimately fail and the disease progresses to lethal castration-resistant prostate cancer (CRPC). The mechanisms that drive CRPC are incompletely understood, but may involve constitutively active AR splice variants that lack the LBD. The AR N-terminal domain (NTD) is essential for AR activity, but targeting this domain with small-molecule inhibitors is complicated by its intrin ...[more]