Linking MLL and the HGF-MET signaling pathway in liver cancer.
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ABSTRACT:
SUBMITTER: Marquardt JU
PROVIDER: S-EPMC3696572 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Publications
Linking MLL and the HGF-MET signaling pathway in liver cancer.
Marquardt Jens U JU Thorgeirsson Snorri S SS
The Journal of clinical investigation 20130624 7
Mixed-lineage leukemia (MLL; also known as myeloid/lymphoid), the human homolog of trithorax in Drosophila, is a transcriptional coactivator that plays an essential role during early development and hematopoiesis. Furthermore, MLL is critically involved in the epigenetic regulation of cell cycle, senescence, DNA damage, and stem cell self-renewal. Chromosomal aberrations of MLL in acute leukemias are well documented, but the role of this gene in solid malignancies remains unclear. In this issue ...[more]
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