Ontology highlight
ABSTRACT:
SUBMITTER: Artyukhin AB
PROVIDER: S-EPMC3696653 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Artyukhin Alexander B AB Yim Joshua J JJ Srinivasan Jagan J Izrayelit Yevgeniy Y Bose Neelanjan N von Reuss Stephan H SH Jo Yeara Y Jordan James M JM Baugh L Ryan LR Cheong Micheong M Sternberg Paul W PW Avery Leon L Schroeder Frank C FC
The Journal of biological chemistry 20130520 26
The ascarosides, small-molecule signals derived from combinatorial assembly of primary metabolism-derived building blocks, play a central role in Caenorhabditis elegans biology and regulate many aspects of development and behavior in this model organism as well as in other nematodes. Using HPLC-MS/MS-based targeted metabolomics, we identified novel ascarosides incorporating a side chain derived from succinylation of the neurotransmitter octopamine. These compounds, named osas#2, osas#9, and osas ...[more]