Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
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ABSTRACT:
SUBMITTER: den Hoed M
PROVIDER: S-EPMC3696959 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Publications
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
den Hoed Marcel M Eijgelsheim Mark M Esko Tõnu T Brundel Bianca J J M BJ Peal David S DS Evans David M DM Nolte Ilja M IM Segrè Ayellet V AV Holm Hilma H Handsaker Robert E RE Westra Harm-Jan HJ Johnson Toby T Isaacs Aaron A Yang Jian J Lundby Alicia A Zhao Jing Hua JH Kim Young Jin YJ Go Min Jin MJ Almgren Peter P Bochud Murielle M Boucher Gabrielle G Cornelis Marilyn C MC Gudbjartsson Daniel D Hadley David D van der Harst Pim P Hayward Caroline C den Heijer Martin M Igl Wilmar W Jackson Anne U AU Kutalik Zoltán Z Luan Jian'an J Kemp John P JP Kristiansson Kati K Ladenvall Claes C Lorentzon Mattias M Montasser May E ME Njajou Omer T OT O'Reilly Paul F PF Padmanabhan Sandosh S St Pourcain Beate B Rankinen Tuomo T Salo Perttu P Tanaka Toshiko T Timpson Nicholas J NJ Vitart Veronique V Waite Lindsay L Wheeler William W Zhang Weihua W Draisma Harmen H M HH Feitosa Mary F MF Kerr Kathleen F KF Lind Penelope A PA Mihailov Evelin E Onland-Moret N Charlotte NC Song Ci C Weedon Michael N MN Xie Weijia W Yengo Loic L Absher Devin D Albert Christine M CM Alonso Alvaro A Arking Dan E DE de Bakker Paul I W PI Balkau Beverley B Barlassina Cristina C Benaglio Paola P Bis Joshua C JC Bouatia-Naji Nabila N Brage Søren S Chanock Stephen J SJ Chines Peter S PS Chung Mina M Darbar Dawood D Dina Christian C Dörr Marcus M Elliott Paul P Felix Stephan B SB Fischer Krista K Fuchsberger Christian C de Geus Eco J C EJ Goyette Philippe P Gudnason Vilmundur V Harris Tamara B TB Hartikainen Anna-Liisa AL Havulinna Aki S AS Heckbert Susan R SR Hicks Andrew A AA Hofman Albert A Holewijn Suzanne S Hoogstra-Berends Femke F Hottenga Jouke-Jan JJ Jensen Majken K MK Johansson Asa A Junttila Juhani J Kääb Stefan S Kanon Bart B Ketkar Shamika S Khaw Kay-Tee KT Knowles Joshua W JW Kooner Angrad S AS Kors Jan A JA Kumari Meena M Milani Lili L Laiho Päivi P Lakatta Edward G EG Langenberg Claudia C Leusink Maarten M Liu Yongmei Y Luben Robert N RN Lunetta Kathryn L KL Lynch Stacey N SN Markus Marcello R P MR Marques-Vidal Pedro P Mateo Leach Irene I McArdle Wendy L WL McCarroll Steven A SA Medland Sarah E SE Miller Kathryn A KA Montgomery Grant W GW Morrison Alanna C AC Müller-Nurasyid Martina M Navarro Pau P Nelis Mari M O'Connell Jeffrey R JR O'Donnell Christopher J CJ Ong Ken K KK Newman Anne B AB Peters Annette A Polasek Ozren O Pouta Anneli A Pramstaller Peter P PP Psaty Bruce M BM Rao Dabeeru C DC Ring Susan M SM Rossin Elizabeth J EJ Rudan Diana D Sanna Serena S Scott Robert A RA Sehmi Jaban S JS Sharp Stephen S Shin Jordan T JT Singleton Andrew B AB Smith Albert V AV Soranzo Nicole N Spector Tim D TD Stewart Chip C Stringham Heather M HM Tarasov Kirill V KV Uitterlinden André G AG Vandenput Liesbeth L Hwang Shih-Jen SJ Whitfield John B JB Wijmenga Cisca C Wild Sarah H SH Willemsen Gonneke G Wilson James F JF Witteman Jacqueline C M JC Wong Andrew A Wong Quenna Q Jamshidi Yalda Y Zitting Paavo P Boer Jolanda M A JM Boomsma Dorret I DI Borecki Ingrid B IB van Duijn Cornelia M CM Ekelund Ulf U Forouhi Nita G NG Froguel Philippe P Hingorani Aroon A Ingelsson Erik E Kivimaki Mika M Kronmal Richard A RA Kuh Diana D Lind Lars L Martin Nicholas G NG Oostra Ben A BA Pedersen Nancy L NL Quertermous Thomas T Rotter Jerome I JI van der Schouw Yvonne T YT Verschuren W M Monique WM Walker Mark M Albanes Demetrius D Arnar David O DO Assimes Themistocles L TL Bandinelli Stefania S Boehnke Michael M de Boer Rudolf A RA Bouchard Claude C Caulfield W L Mark WL Chambers John C JC Curhan Gary G Cusi Daniele D Eriksson Johan J Ferrucci Luigi L van Gilst Wiek H WH Glorioso Nicola N de Graaf Jacqueline J Groop Leif L Gyllensten Ulf U Hsueh Wen-Chi WC Hu Frank B FB Huikuri Heikki V HV Hunter David J DJ Iribarren Carlos C Isomaa Bo B Jarvelin Marjo-Riitta MR Jula Antti A Kähönen Mika M Kiemeney Lambertus A LA van der Klauw Melanie M MM Kooner Jaspal S JS Kraft Peter P Iacoviello Licia L Lehtimäki Terho T Lokki Marja-Liisa L ML Mitchell Braxton D BD Navis Gerjan G Nieminen Markku S MS Ohlsson Claes C Poulter Neil R NR Qi Lu L Raitakari Olli T OT Rimm Eric B EB Rioux John D JD Rizzi Federica F Rudan Igor I Salomaa Veikko V Sever Peter S PS Shields Denis C DC Shuldiner Alan R AR Sinisalo Juha J Stanton Alice V AV Stolk Ronald P RP Strachan David P DP Tardif Jean-Claude JC Thorsteinsdottir Unnur U Tuomilehto Jaako J van Veldhuisen Dirk J DJ Virtamo Jarmo J Viikari Jorma J Vollenweider Peter P Waeber Gérard G Widen Elisabeth E Cho Yoon Shin YS Olsen Jesper V JV Visscher Peter M PM Willer Cristen C Franke Lude L Erdmann Jeanette J Thompson John R JR Pfeufer Arne A Sotoodehnia Nona N Newton-Cheh Christopher C Ellinor Patrick T PT Stricker Bruno H Ch BH Metspalu Andres A Perola Markus M Beckmann Jacques S JS Smith George Davey GD Stefansson Kari K Wareham Nicholas J NJ Munroe Patricia B PB Sibon Ody C M OC Milan David J DJ Snieder Harold H Samani Nilesh J NJ Loos Ruth J F RJ
Nature genetics 20130414 6
Elevated resting heart rate is associated with greater risk of cardiovascular disease and mortality. In a 2-stage meta-analysis of genome-wide association studies in up to 181,171 individuals, we identified 14 new loci associated with heart rate and confirmed associations with all 7 previously established loci. Experimental downregulation of gene expression in Drosophila melanogaster and Danio rerio identified 20 genes at 11 loci that are relevant for heart rate regulation and highlight a role f ...[more]