Ontology highlight
ABSTRACT:
SUBMITTER: Grossman I
PROVIDER: S-EPMC3697113 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Grossman Iris I Sullivan Patrick F PF Walley Nicole N Liu Youfang Y Dawson Jeffrey R JR Gumbs Curtis C Gaedigk Andrea A Leeder J Steven JS McEvoy Joseph P JP Weale Michael E ME Goldstein David B DB
Genetics in medicine : official journal of the American College of Medical Genetics 20081001 10
<h4>Purpose</h4>To evaluate systematically in real clinical settings whether functional genetic variations in drug metabolizing enzymes influence optimized doses, efficacy, and safety of antipsychotic medications.<h4>Methods</h4>DNA was collected from 750 patients with chronic schizophrenia treated with five antipsychotic drugs (olanzapine, quetiapine, risperidone, ziprasidone, and perphenazine) as part of the Clinical Antipsychotic Trials of Intervention Effectiveness study. Doses for each of t ...[more]