Ontology highlight
ABSTRACT:
SUBMITTER: Aouri M
PROVIDER: S-EPMC3697367 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Aouri Manel M Moradpour Darius D Cavassini Matthias M Mercier Thomas T Buclin Thierry T Csajka Chantal C Telenti Amalio A Rauch Andri A Decosterd Laurent A LA
Antimicrobial agents and chemotherapy 20130429 7
New directly acting antivirals (DAAs) that inhibit hepatitis C virus (HCV) replication are increasingly used for the treatment of chronic hepatitis C. A marked pharmacokinetic variability and a high potential for drug-drug interactions between DAAs and numerous drug classes have been identified. In addition, ribavirin (RBV), commonly associated with hemolytic anemia, often requires dose adjustment, advocating for therapeutic drug monitoring (TDM) in patients under combined antiviral therapy. How ...[more]