Ontology highlight
ABSTRACT:
SUBMITTER: Tang L
PROVIDER: S-EPMC3697826 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Tang Li L Gabrielson Nathan P NP Uckun Fatih M FM Fan Timothy M TM Cheng Jianjun J
Molecular pharmaceutics 20130212 3
The size of a nanomedicine strongly correlates with its biodistribution, tissue penetration, and cell uptake. However, there is limited understanding how the size of nanomedicine impacts the overall antitumor efficacy. We designed and synthesized camptothecin-silica nanoconjugates (Cpt-NCs) with monodisperse particle sizes of 50 and 200 nm, two representative sizes commonly used in drug delivery, and evaluated their antitumor efficacy in murine tumor models. Our studies revealed that the 50 nm C ...[more]