Different gene regulation strategies revealed by analysis of binding motifs.
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ABSTRACT:
SUBMITTER: Wunderlich Z
PROVIDER: S-EPMC3697852 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Publications
Different gene regulation strategies revealed by analysis of binding motifs.
Wunderlich Zeba Z Mirny Leonid A LA
Trends in genetics : TIG 20091006 10
Coordinated regulation of gene expression relies on transcription factors (TFs) binding to specific DNA sites. Our large-scale information-theoretical analysis of > 950 TF-binding motifs demonstrates that prokaryotes and eukaryotes use strikingly different strategies to target TFs to specific genome locations. Although bacterial TFs can recognize a specific DNA site in the genomic background, eukaryotic TFs exhibit widespread, nonfunctional binding and require clustering of sites to achieve spec ...[more]
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