Assessing genome-wide statistical significance for large p small n problems.
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ABSTRACT: Assessing genome-wide statistical significance is an important issue in genetic studies. We describe a new resampling approach for determining the appropriate thresholds for statistical significance. Our simulation results demonstrate that the proposed approach accurately controls the genome-wide type I error rate even under the large p small n situations.
SUBMITTER: Diao G
PROVIDER: S-EPMC3697980 | biostudies-literature |
REPOSITORIES: biostudies-literature
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