Ontology highlight
ABSTRACT:
SUBMITTER: Yoon K
PROVIDER: S-EPMC3698504 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Yoon Kwiyeom K Lee Sunghoon S Han Tae-Su TS Moon So Yeon SY Yun Sun Mi SM Kong Seong-Ho SH Jho Sungwoong S Choe Jinny J Yu Jieun J Lee Hyuk-Joon HJ Park Ji Hyun JH Kim Hak-Min HM Lee So Yeun SY Park Jongsun J Kim Woo-Ho WH Bhak Jong J Yang Han-Kwang HK Kim Seong-Jin SJ
Genome research 20130604 7
Microsatellite instability (MSI) is a critical mechanism that drives genetic aberrations in cancer. To identify the entire MS mutation, we performed the first comprehensive genome- and transcriptome-wide analyses of mutations associated with MSI in Korean gastric cancer cell lines and primary tissues. We identified 18,377 MS mutations of five or more repeat nucleotides in coding sequences and untranslated regions of genes, and discovered 139 individual genes whose expression was down-regulated i ...[more]