Ontology highlight
ABSTRACT:
SUBMITTER: Falta MT
PROVIDER: S-EPMC3698527 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Falta Michael T MT Pinilla Clemencia C Mack Douglas G DG Tinega Alex N AN Crawford Frances F Giulianotti Marc M Santos Radleigh R Clayton Gina M GM Wang Yuxiao Y Zhang Xuewu X Maier Lisa A LA Marrack Philippa P Kappler John W JW Fontenot Andrew P AP
The Journal of experimental medicine 20130701 7
Chronic beryllium disease (CBD) is a granulomatous disorder characterized by an influx of beryllium (Be)-specific CD4⁺ T cells into the lung. The vast majority of these T cells recognize Be in an HLA-DP–restricted manner, and peptide is required for T cell recognition. However, the peptides that stimulate Be-specific T cells are unknown. Using positional scanning libraries and fibroblasts expressing HLA-DP2, the most prevalent HLA-DP molecule linked to disease, we identified mimotopes and endoge ...[more]