Ontology highlight
ABSTRACT:
SUBMITTER: Xu JM
PROVIDER: S-EPMC3699040 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Xu Jian-Ming JM Wang Yan Y Ge Fei-Jiao FJ Lin Li L Liu Ze-Yuan ZY Sharma Manish R MR
World journal of gastroenterology 20130601 24
Many studies have demonstrated the impact of UGT1A1 on toxicity of irinotecan. In particular, patients bearing UGT1A1 28 (TA 7/7) have a higher risk of severe neutropenia and diarrhea. Based on this, prescribers of irinotecan are advised that patients with UGT1A1 28 (TA 7/7) should start with a reduced dose of irinotecan, although a particular dose is not specified. Research in Asian countries has shown a lower incidence of UGT1A1 28 (TA 7/7), while UGT1A1 6 (A/A) is more often found and is asso ...[more]