Ontology highlight
ABSTRACT:
SUBMITTER: Sheu WH
PROVIDER: S-EPMC3699066 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Sheu Wayne H-H WH Kuo Jane Z JZ Lee I-Te IT Hung Yi-Jen YJ Lee Wen-Jane WJ Tsai Hin-Yeung HY Wang J-S JS Goodarzi Mark O MO Klein Ronald R Klein Barbara E K BE Ipp Eli E Lin Shin-Yi SY Guo Xiuqing X Hsieh Chang-Hsun CH Taylor Kent D KD Fu Chia-Po CP Rotter Jerome I JI Chen Yii-Der I YD
Human molecular genetics 20130404 15
Diabetic retinopathy (DR) is a leading cause of preventable blindness in adults. To identify genetic contributions in DR, we studied 2071 type 2 diabetics. We first conducted a genome-wide association study of 1007 individuals, comparing 570 subjects with ≥8 years duration without DR (controls) with 437 PDR (cases) in the Chinese discovery cohort. Cases and controls were similar for HbA1c, diabetes duration and body mass index. Association analysis with imputed data identified three novel loci: ...[more]