Protection by immunoglobulin dual-affinity retargeting antibodies against dengue virus.
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ABSTRACT:
SUBMITTER: Brien JD
PROVIDER: S-EPMC3700316 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Publications
Protection by immunoglobulin dual-affinity retargeting antibodies against dengue virus.
Brien James D JD Sukupolvi-Petty Soila S Williams Katherine L KL Lam Chia-Ying Kao CY Schmid Michael A MA Johnson Syd S Harris Eva E Diamond Michael S MS
Journal of virology 20130508 13
Dengue viruses are the most common arthropod-transmitted viral infection, with an estimated 390 million human infections annually and ∼3.6 billion people at risk. Currently, there are no approved vaccines or therapeutics available to control the global dengue virus disease burden. In this study, we demonstrate the binding, neutralizing activity, and therapeutic capacity of a novel bispecific dual-affinity retargeting molecule (DART) that limits infection of all four serotypes of dengue virus. ...[more]
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