Ontology highlight
ABSTRACT:
SUBMITTER: Chen L
PROVIDER: S-EPMC3700321 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Cancer cell 20130601 6
B cell receptor (BCR) signaling pathway components represent promising treatment targets in diffuse large B cell lymphoma (DLBCL) and additional B cell tumors. BCR signaling activates spleen tyrosine kinase (SYK) and downstream pathways including PI3K/AKT and NF-κB. In previous studies, chemical SYK blockade selectively decreased BCR signaling and induced apoptosis of BCR-dependent DLBCLs. Herein, we characterize distinct SYK/PI3K-dependent survival pathways in DLBCLs with high or low baseline N ...[more]