The role of STAT3 activation in modulating the immune microenvironment of GBM.
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ABSTRACT:
SUBMITTER: See AP
PROVIDER: S-EPMC3700337 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Publications
The role of STAT3 activation in modulating the immune microenvironment of GBM.
See Alfred P AP Han James E JE Phallen Jillian J Binder Zev Z Gallia Gary G Pan Fan F Jinasena Dilini D Jackson Christopher C Belcaid Zineb Z Jeong Sung Jin SJ Gottschalk Chelsea C Zeng Jing J Ruzevick Jacob J Nicholas Sarah S Kim Young Y Albesiano Emilia E Pardoll Drew M DM Lim Michael M
Journal of neuro-oncology 20121025 3
Glioblastoma multiforme (GBM) modulates the immune system to engance its malignant potential. Signal transducer and activator of transcription 3 (STAT3) activation is a regulatory node in modulating the immune microenvironment in several human tumors, including GBM. To investigate whether STAT3 inhibition might enhance anti-tumor responses, we inhibited STAT3 signaling using small interfering RNA against STAT3. We tested the human GBM cell lines U87, U251, and HS683, which are known to constitut ...[more]
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