Ontology highlight
ABSTRACT:
SUBMITTER: Cheng G
PROVIDER: S-EPMC3700358 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Cheng Gang G Zielonka Jacek J Dranka Brian P BP McAllister Donna D Mackinnon A Craig AC Joseph Joy J Kalyanaraman Balaraman B
Cancer research 20120319 10
Cancer cells are long known to exhibit increased aerobic glycolysis, but glycolytic inhibition has not offered a viable chemotherapeutic strategy in part because of the systemic toxicity of antiglycolytic agents. However, recent studies suggest that a combined inhibition of glycolysis and mitochondrial function may help overcome this issue. In this study, we investigated the chemotherapeutic efficacies of mitochondria-targeted drugs (MTD) in combination with 2-deoxy-d-glucose (2-DG), a compound ...[more]