Ontology highlight
ABSTRACT:
SUBMITTER: Kluge MA
PROVIDER: S-EPMC3700369 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Kluge Matthew A MA Fetterman Jessica L JL Vita Joseph A JA
Circulation research 20130401 8
In contrast to their role in cell types with higher energy demands, mitochondria in endothelial cells primarily function in signaling cellular responses to environmental cues. This article provides an overview of key aspects of mitochondrial biology in endothelial cells, including subcellular location, biogenesis, dynamics, autophagy, reactive oxygen species production and signaling, calcium homeostasis, regulated cell death, and heme biosynthesis. In each section, we introduce key concepts and ...[more]