Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC3700415 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Wang Xidao X Zhang Jie J Eberhart Derek D Urban Rochelle R Meda Karuna K Solorzano Carlos C Yamanaka Hiroki H Rice Dennis D Basbaum Allan I AI
Neuron 20130401 2
To what extent dorsal horn interneurons contribute to the modality specific processing of pain and itch messages is not known. Here, we report that loxp/cre-mediated CNS deletion of TR4, a testicular orphan nuclear receptor, results in loss of many excitatory interneurons in the superficial dorsal horn but preservation of primary afferents and spinal projection neurons. The interneuron loss is associated with a near complete absence of supraspinally integrated pain and itch behaviors, elevated m ...[more]