Ontology highlight
ABSTRACT:
SUBMITTER: Le TN
PROVIDER: S-EPMC3700434 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Le Trang N TN Elsea Sarah H SH Romero Roberto R Chaiworapongsa Tinnakorn T Francis Gary L GL
Genetic testing and molecular biomarkers 20130507 7
<h4>Aims</h4>Human placental lactogen (hPL) acts via the prolactin receptor (PRLR) on maternal β-cells to mediate increases in β-cell mass and function during normal pregnancy. This interaction between hPL and PRLR is essential to maintain normal glucose homeostasis and to address the increased metabolic demands of pregnancy. Given the importance of the PRLR-hPL axis in pancreatic islet cell adaptation to pregnancy, we hypothesized that genetic variation in the PRLR gene could influence risk of ...[more]