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Impulsiveness mediates the association between GABRA2 SNPs and lifetime alcohol problems.


ABSTRACT: Genetic variants in GABRA2 have previously been shown to be associated with alcohol measures, electroencephalography (EEG) ? waves and impulsiveness-related traits. Impulsiveness is a behavioral risk factor for alcohol and other substance abuse. Here, we tested association between 11 variants in GABRA2 with NEO-impulsiveness and problem drinking. Our sample of 295 unrelated adult subjects was from a community of families with at least one male with DSM-IV alcohol use diagnosis, and from a socioeconomically comparable control group. Ten GABRA2 SNPs (single-nucleotide polymorphisms) were associated with the NEO-impulsiveness (P?

SUBMITTER: Villafuerte S 

PROVIDER: S-EPMC3700576 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature

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Impulsiveness mediates the association between GABRA2 SNPs and lifetime alcohol problems.

Villafuerte S S   Strumba V V   Stoltenberg S F SF   Zucker R A RA   Burmeister M M  

Genes, brain, and behavior 20130417 5


Genetic variants in GABRA2 have previously been shown to be associated with alcohol measures, electroencephalography (EEG) β waves and impulsiveness-related traits. Impulsiveness is a behavioral risk factor for alcohol and other substance abuse. Here, we tested association between 11 variants in GABRA2 with NEO-impulsiveness and problem drinking. Our sample of 295 unrelated adult subjects was from a community of families with at least one male with DSM-IV alcohol use diagnosis, and from a socioe  ...[more]

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