Impulsiveness mediates the association between GABRA2 SNPs and lifetime alcohol problems.
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ABSTRACT:
SUBMITTER: Villafuerte S
PROVIDER: S-EPMC3700576 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
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Impulsiveness mediates the association between GABRA2 SNPs and lifetime alcohol problems.
Villafuerte S S Strumba V V Stoltenberg S F SF Zucker R A RA Burmeister M M
Genes, brain, and behavior 20130417 5
Genetic variants in GABRA2 have previously been shown to be associated with alcohol measures, electroencephalography (EEG) β waves and impulsiveness-related traits. Impulsiveness is a behavioral risk factor for alcohol and other substance abuse. Here, we tested association between 11 variants in GABRA2 with NEO-impulsiveness and problem drinking. Our sample of 295 unrelated adult subjects was from a community of families with at least one male with DSM-IV alcohol use diagnosis, and from a socioe ...[more]
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