Ontology highlight
ABSTRACT:
SUBMITTER: Dupuy AJ
PROVIDER: S-EPMC3700628 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Dupuy Adam J AJ Rogers Laura M LM Kim Jinsil J Nannapaneni Kishore K Starr Timothy K TK Liu Pentao P Largaespada David A DA Scheetz Todd E TE Jenkins Nancy A NA Copeland Neal G NG
Cancer research 20091006 20
Recent advances in cancer therapeutics stress the need for a better understanding of the molecular mechanisms driving tumor formation. This can be accomplished by obtaining a more complete description of the genes that contribute to cancer. We previously described an approach using the Sleeping Beauty (SB) transposon system to model hematopoietic malignancies in mice. Here, we describe modifications of the SB system that provide additional flexibility in generating mouse models of cancer. First, ...[more]