Ontology highlight
ABSTRACT:
SUBMITTER: Paz JT
PROVIDER: S-EPMC3700812 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Paz Jeanne T JT Davidson Thomas J TJ Frechette Eric S ES Delord Bruno B Parada Isabel I Peng Kathy K Deisseroth Karl K Huguenard John R JR
Nature neuroscience 20121107 1
Cerebrocortical injuries such as stroke are a major source of disability. Maladaptive consequences can result from post-injury local reorganization of cortical circuits. For example, epilepsy is a common sequela of cortical stroke, but the mechanisms responsible for seizures following cortical injuries remain unknown. In addition to local reorganization, long-range, extra-cortical connections might be critical for seizure maintenance. In rats, we found that the thalamus, a structure that is remo ...[more]