Ontology highlight
ABSTRACT:
SUBMITTER: Verschoor CP
PROVIDER: S-EPMC3701116 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Verschoor Chris P CP Johnstone Jennie J Millar Jamie J Dorrington Michael G MG Habibagahi Mojtaba M Lelic Alina A Loeb Mark M Bramson Jonathan L JL Bowdish Dawn M E DM
Journal of leukocyte biology 20130122 4
As we age, the composition of our peripheral leukocytes changes dramatically. Many of these alterations contribute to the general immune dysfunction that burdens the elderly, which in turn, contributes to increased susceptibility to disease. MDSCs represent a heterogeneous population of immunosuppressive leukocytes that are elevated in the peripheral blood of cancer patients. Given the relation between cancer incidence and age, this study examined the frequency of peripheral blood CD33(+)HLA-DR( ...[more]