Degradation of IF1 controls energy metabolism during osteogenic differentiation of stem cells.
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ABSTRACT:
SUBMITTER: Sanchez-Arago M
PROVIDER: S-EPMC3701239 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
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Degradation of IF1 controls energy metabolism during osteogenic differentiation of stem cells.
Sánchez-Aragó María M García-Bermúdez Javier J Martínez-Reyes Inmaculada I Santacatterina Fulvio F Cuezva José M JM
EMBO reports 20130531 7
Differentiation of human mesenchymal stem cells (hMSCs) requires the rewiring of energy metabolism. Herein, we demonstrate that the ATPase inhibitory factor 1 (IF1) is expressed in hMSCs and in prostate and colon stem cells but is not expressed in the differentiated cells. IF1 inhibits oxidative phosphorylation and regulates the activity of aerobic glycolysis in hMSCs. Silencing of IF1 in hMSCs mimics the metabolic changes observed in osteocytes and accelerates cellular differentiation. Activati ...[more]
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