The impact of orbitofrontal dysfunction on cocaine addiction.
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ABSTRACT:
SUBMITTER: Lucantonio F
PROVIDER: S-EPMC3701259 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Publications
The impact of orbitofrontal dysfunction on cocaine addiction.
Lucantonio Federica F Stalnaker Thomas A TA Shaham Yavin Y Niv Yael Y Schoenbaum Geoffrey G
Nature neuroscience 20120122 3
Cocaine addiction is characterized by poor judgment and maladaptive decision-making. Here we review evidence implicating the orbitofrontal cortex in such behavior. This evidence suggests that cocaine-induced changes in orbitofrontal cortex disrupt the representation of states and transition functions that form the basis of flexible and adaptive 'model-based' behavioral control. By impairing this function, cocaine exposure leads to an overemphasis on less flexible, maladaptive 'model-free' contro ...[more]
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