Dataset Information

Delayed gastric emptying and reduced postprandial small bowel water content of equicaloric whole meal bread versus rice meals in healthy subjects: novel MRI insights.

ABSTRACT:

Background/objectives

Postprandial bloating is a common symptom in patients with functional gastrointestinal (GI) diseases. Whole meal bread (WMB) often aggravates such symptoms though the mechanisms are unclear. We used magnetic resonance imaging (MRI) to monitor the intragastric fate of a WMB meal (11% bran) compared with a rice pudding (RP) meal.

Subjects/methods

Twelve healthy volunteers completed this randomised crossover study. They fasted overnight and after an initial MRI scan consumed a glass of orange juice with a 2267?kJ WMB or an equicaloric RP meal. Subjects underwent serial MRI scans every 45?min up to 270?min to assess gastric volumes and small bowel water content, and completed a GI symptom questionnaire.

Results

The MRI intragastric appearance of the two meals was markedly different. The WMB meal formed a homogeneous dark bolus with brighter liquid signal surrounding it. The RP meal separated into an upper liquid layer and a lower particulate layer allowing more rapid emptying of the liquid compared with solid phase (sieving). The WMB meal had longer gastric half-emptying times (132±8?min) compared with the RP meal (104±7?min), P<0.008. The WMB meal was associated with markedly reduced MRI-visible small bowel free mobile water content compared with the RP meal, P<0.0001.

Conclusions

WMB bread forms a homogeneous bolus in the stomach, which inhibits gastric sieving and hence empties slower than the equicaloric rice meal. These properties may explain why wheat causes postprandial bloating and could be exploited to design foods that prolong satiation.

SUBMITTER: Marciani L

PROVIDER: S-EPMC3701291 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature

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Publications

Delayed gastric emptying and reduced postprandial small bowel water content of equicaloric whole meal bread versus rice meals in healthy subjects: novel MRI insights.

Marciani L L Pritchard S E SE Hellier-Woods C C Costigan C C Hoad C L CL Gowland P A PA Spiller R C RC

European journal of clinical nutrition 20130417 7

<h4>Background/objectives</h4>Postprandial bloating is a common symptom in patients with functional gastrointestinal (GI) diseases. Whole meal bread (WMB) often aggravates such symptoms though the mechanisms are unclear. We used magnetic resonance imaging (MRI) to monitor the intragastric fate of a WMB meal (11% bran) compared with a rice pudding (RP) meal.<h4>Subjects/methods</h4>Twelve healthy volunteers completed this randomised crossover study. They fasted overnight and after an initial MRI ...[more]

PMID: 23594839

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Dataset Information

Delayed gastric emptying and reduced postprandial small bowel water content of equicaloric whole meal bread versus rice meals in healthy subjects: novel MRI insights.

Background/objectives

Subjects/methods

Results

Conclusions

Publications

Delayed gastric emptying and reduced postprandial small bowel water content of equicaloric whole meal bread versus rice meals in healthy subjects: novel MRI insights.

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