Ontology highlight
ABSTRACT:
SUBMITTER: Sharma A
PROVIDER: S-EPMC3701375 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Beilstein journal of organic chemistry 20130626
A practical, mild and efficient protocol for the Pictet-Spengler reaction catalyzed by cyanuric chloride (trichloro-1,3,5-triazine, TCT) is described. The 6-endo cyclization of tryptophan/tryptamine and modified Pictet-Spengler substrates with both electron-withdrawing and electron-donating aldehydes was carried out by using a catalytic amount of TCT (10 mol %) in DMSO under a nitrogen atmosphere. TCT catalyzed the Pictet-Spengler reaction involving electron-donating aldehydes in excellent yield ...[more]