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Synthesis of the tetracyclic core of Illicium sesquiterpenes using an organocatalyzed asymmetric Robinson annulation.

ABSTRACT: An enantioselective synthesis of the core framework of neurotrophic Illicium majucin-type sesquiterpenes is described here. This strategy is based on an organocatalyzed asymmetric Robinson annulation and provides an efficient approach for a diversity-oriented synthesis of Illicium natural products that holds remarkable therapeutic potential for neurodegenerative diseases.

SUBMITTER: Trzoss L

PROVIDER: S-EPMC3701413 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Synthesis of the tetracyclic core of Illicium sesquiterpenes using an organocatalyzed asymmetric Robinson annulation.

Trzoss Lynnie L Xu Jing J Lacoske Michelle H MH Theodorakis Emmanuel A EA

Beilstein journal of organic chemistry 20130612

An enantioselective synthesis of the core framework of neurotrophic Illicium majucin-type sesquiterpenes is described here. This strategy is based on an organocatalyzed asymmetric Robinson annulation and provides an efficient approach for a diversity-oriented synthesis of Illicium natural products that holds remarkable therapeutic potential for neurodegenerative diseases. ...[more]

PMID: 23843905

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