Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers.
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ABSTRACT:
SUBMITTER: Ting DT
PROVIDER: S-EPMC3701432 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Publications
Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers.
Ting David T DT Lipson Doron D Paul Suchismita S Brannigan Brian W BW Akhavanfard Sara S Coffman Erik J EJ Contino Gianmarco G Deshpande Vikram V Iafrate A John AJ Letovsky Stan S Rivera Miguel N MN Bardeesy Nabeel N Maheswaran Shyamala S Haber Daniel A DA
Science (New York, N.Y.) 20110113 6017
Satellite repeats in heterochromatin are transcribed into noncoding RNAs that have been linked to gene silencing and maintenance of chromosomal integrity. Using digital gene expression analysis, we showed that these transcripts are greatly overexpressed in mouse and human epithelial cancers. In 8 of 10 mouse pancreatic ductal adenocarcinomas (PDACs), pericentromeric satellites accounted for a mean 12% (range 1 to 50%) of all cellular transcripts, a mean 40-fold increase over that in normal tissu ...[more]
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