Dataset Information

Iron status and Helicobacter pylori infection in symptomatic children: an international multi-centered study.

ABSTRACT:

Objective

Iron deficiency (ID) and iron deficiency anaemia (IDA) are global major public health problems, particularly in developing countries. Whilst an association between H. pylori infection and ID/IDA has been proposed in the literature, currently there is no consensus. We studied the effects of H. pylori infection on ID/IDA in a cohort of children undergoing upper gastrointestinal endoscopy for upper abdominal pain in two developing and one developed country.

Methods

In total 311 children (mean age 10.7±3.2 years) from Latin America--Belo Horizonte/Brazil (n?=?125), Santiago/Chile (n?=?105)--and London/UK (n?=?81), were studied. Gastric and duodenal biopsies were obtained for evaluation of histology and H. pylori status and blood samples for parameters of ID/IDA.

Results

The prevalence of H. pylori infection was 27.7% being significantly higher (p<0.001) in Latin America (35%) than in UK (7%). Multiple linear regression models revealed H. pylori infection as a significant predictor of low ferritin and haemoglobin concentrations in children from Latin-America. A negative correlation was observed between MCV (r?=?-0.26; p?=?0.01) and MCH (r?=?-0.27; p?=?0.01) values and the degree of antral chronic inflammation, and between MCH and the degree of corpus chronic (r?=?-0.29, p?=?0.008) and active (r?=?-0.27, p?=?0.002) inflammation.

Conclusions

This study demonstrates that H. pylori infection in children influences the serum ferritin and haemoglobin concentrations, markers of early depletion of iron stores and anaemia respectively.

SUBMITTER: Queiroz DM

PROVIDER: S-EPMC3701645 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Publications

Iron status and Helicobacter pylori infection in symptomatic children: an international multi-centered study.

Queiroz Dulciene Maria Magalhaes DM Harris Paul R PR Sanderson Ian R IR Windle Henry J HJ Walker Marjorie M MM Rocha Andreia Maria Camargos AM Rocha Gifone Aguiar GA Carvalho Simone Diniz SD Bittencourt Paulo Fernando Souto PF de Castro Lucia Porto Fonseca LP Villagrán Andrea A Serrano Carolina C Kelleher Dermot D Crabtree Jean E JE

PloS one 20130704 7

<h4>Objective</h4>Iron deficiency (ID) and iron deficiency anaemia (IDA) are global major public health problems, particularly in developing countries. Whilst an association between H. pylori infection and ID/IDA has been proposed in the literature, currently there is no consensus. We studied the effects of H. pylori infection on ID/IDA in a cohort of children undergoing upper gastrointestinal endoscopy for upper abdominal pain in two developing and one developed country.<h4>Methods</h4>In total ...[more]

PMID: 23861946

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Project description:BackgroundThe protozoan parasite Giardia intestinalis and the pathogenic bacterium Helicobacter pylori are well known for their high prevalences in human hosts worldwide. The prevalence of both organisms is known to peak in densely populated, low resource settings and children are infected early in life. Different Giardia genotypes/assemblages have been associated with different symptoms and H. pylori with induction of cancer. Despite this, not much data are available from sub-Saharan Africa with regards to the prevalence of different G. intestinalis assemblages and their potential association with H. pylori infections.Methodology/principal findingsFecal samples from 427 apparently healthy children, 0-12 years of age, living in urban Kampala, Uganda were analyzed for the presence of H. pylori and G. intestinalis. G. intestinalis was found in 86 (20.1%) out of the children and children age 1<5 years had the highest rates of colonization. H. pylori was found in 189 (44.3%) out of the 427 children and there was a 3-fold higher risk of concomitant G. intestinalis and H. pylori infections compared to non-concomitant G. intestinalis infection, OR = 2.9 (1.7-4.8). No significant association was found in the studied population with regard to the presence of Giardia and gender, type of toilet, source of drinking water or type of housing. A panel of 45 G. intestinalis positive samples was further analyzed using multi-locus genotyping (MLG) on three loci, combined with assemblage-specific analyses. Giardia MLG analysis yielded a total of five assemblage AII, 25 assemblage B, and four mixed assemblage infections. The assemblage B isolates were highly genetically variable but no significant association was found between Giardia assemblage type and H. pylori infection.Conclusions/significanceThis study shows that Giardia assemblage B dominates in children in Kampala, Uganda and that the presence of H. pylori is an associated risk factor for G. intestinalis infection.

Dataset Information

Iron status and Helicobacter pylori infection in symptomatic children: an international multi-centered study.

Objective

Methods

Results

Conclusions

Publications

Iron status and Helicobacter pylori infection in symptomatic children: an international multi-centered study.

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