Ontology highlight
ABSTRACT:
SUBMITTER: O'Connor TD
PROVIDER: S-EPMC3701690 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
O'Connor Timothy D TD Kiezun Adam A Bamshad Michael M Rich Stephen S SS Smith Joshua D JD Turner Emily E Leal Suzanne M SM Akey Joshua M JM
PloS one 20130704 7
Advances in next-generation sequencing technology have enabled systematic exploration of the contribution of rare variation to Mendelian and complex diseases. Although it is well known that population stratification can generate spurious associations with common alleles, its impact on rare variant association methods remains poorly understood. Here, we performed exhaustive coalescent simulations with demographic parameters calibrated from exome sequence data to evaluate the performance of nine r ...[more]