Prion-like propagation of protein aggregation and related therapeutic strategies.
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ABSTRACT:
SUBMITTER: Kaufman SK
PROVIDER: S-EPMC3701767 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Publications
Prion-like propagation of protein aggregation and related therapeutic strategies.
Kaufman Sarah K SK Diamond Marc I MI
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20130701 3
Many neurodegenerative diseases are characterized by the progressive accumulation of aggregated protein. Recent evidence suggests the prion-like propagation of protein misfolding underlies the spread of pathology observed in these diseases. This review traces our understanding of the mechanisms that underlie this phenomenon and discusses related therapeutic strategies that derive from it. ...[more]
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