Ontology highlight
ABSTRACT:
SUBMITTER: Harrison JS
PROVIDER: S-EPMC3701885 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Harrison Joseph S JS Higgins Chelsea D CD O'Meara Matthew J MJ Koellhoffer Jayne F JF Kuhlman Brian A BA Lai Jonathan R JR
Structure (London, England : 1993) 20130701 7
Viral fusion proteins undergo dramatic conformational transitions during membrane fusion. For viruses that enter through the endosome, these conformational rearrangements are typically pH sensitive. Here, we provide a comprehensive review of the molecular interactions that govern pH-dependent rearrangements and introduce a paradigm for electrostatic residue pairings that regulate progress through the viral fusion coordinate. Analysis of structural data demonstrates a significant role for side-ch ...[more]