Identification of two maternal transmission ratio distortion loci in pedigrees of the Framingham heart study.
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ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC3701898 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Identification of two maternal transmission ratio distortion loci in pedigrees of the Framingham heart study.
Liu Yang Y Zhang Liangliang L Xu Shuhua S Hu Landian L Hurst Laurence D LD Kong Xiangyin X
Scientific reports 20130101
Transmission ratio distortion (TRD) is indicated by the recovery of alleles in offspring in non-Mendelian proportions. An assumption of Mendelian proportion is central to many methods to identify disease-associated markers. This seems reasonable as, while TRD cases have been occasionally observed in various species few instances have been identified in humans. Here we search for evidence of paternal or maternal TRD with genome-wide SNP data of pedigrees from the Framingham Heart Study. After exc ...[more]
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