Immunogenic tumor cell death induced by chemoradiotherapy: molecular mechanisms and a clinical translation.
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ABSTRACT:
SUBMITTER: Kono K
PROVIDER: S-EPMC3702303 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
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Immunogenic tumor cell death induced by chemoradiotherapy: molecular mechanisms and a clinical translation.
Kono K K Mimura K K Kiessling R R
Cell death & disease 20130620
Chemoradiotherapy can induce immunogenic cell death, triggering danger signals such as high-mobility group box 1 protein, and resulting in T-cell immunity. This concept can potentially be harnessed for clinical therapy to enhance tumor-specific immunity. There is however limited information to translate this theory directly in a clinical setting. In this review, we will discuss and summarize molecular and cellular mechanisms underlying immunogenic tumor cell death induced by chemoradiotherapy, w ...[more]
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