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Determination of absolute configuration of secondary alcohols using thin-layer chromatography.

ABSTRACT: A new implementation of the competing enantioselective conversion (CEC) method was developed to qualitatively determine the absolute configuration of enantioenriched secondary alcohols using thin-layer chromatography. The entire process for the method requires approximately 60 min and utilizes micromole quantities of the secondary alcohol being tested. A number of synthetically relevant secondary alcohols are presented. Additionally, (1)H NMR spectroscopy was conducted on all samples to provide evidence of reaction conversion that supports the qualitative method presented herein.

SUBMITTER: Wagner AJ

PROVIDER: S-EPMC3702370 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature

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Determination of absolute configuration of secondary alcohols using thin-layer chromatography.

Wagner Alexander J AJ Rychnovsky Scott D SD

The Journal of organic chemistry 20130417 9

A new implementation of the competing enantioselective conversion (CEC) method was developed to qualitatively determine the absolute configuration of enantioenriched secondary alcohols using thin-layer chromatography. The entire process for the method requires approximately 60 min and utilizes micromole quantities of the secondary alcohol being tested. A number of synthetically relevant secondary alcohols are presented. Additionally, (1)H NMR spectroscopy was conducted on all samples to provide ...[more]

PMID: 23593963

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