Ontology highlight
ABSTRACT:
SUBMITTER: Fazlollahi F
PROVIDER: S-EPMC3702651 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Fazlollahi Farnoosh F Kim Yong Ho YH Sipos Arnold A Hamm-Alvarez Sarah F SF Borok Zea Z Kim Kwang-Jin KJ Crandall Edward D ED
Nanomedicine : nanotechnology, biology, and medicine 20130220 6
Studies of polystyrene nanoparticle (PNP) trafficking across mouse alveolar epithelial cell monolayers (MAECM) show apical-to-basolateral flux of 20 and 120nm amidine-modified PNP is ~65 times faster than that of 20 and 100nm carboxylate-modified PNP, respectively. Calcium chelation with EGTA has little effect on amidine-modified PNP flux, but increases carboxylate-modified PNP flux ~50-fold. PNP flux is unaffected by methyl-β-cyclodextrin, while ~70% decrease in amidine- (but not carboxylate-) ...[more]