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The GAP between axon pruning and repulsion.

ABSTRACT: Stereotyped axonal pruning and growth cone repulsion, modulators of neuronal connectivity, share many ligands and receptors systems. Riccomagno et al. (2012) show in Cell that common ligands can link functionally specialized downstream pathways, demonstrating that the Rac GAP ?2-Chimaerin is needed in Semaphorin-mediated axonal pruning but not growth cone repulsion.

SUBMITTER: Choe Y 

PROVIDER: S-EPMC3703152 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature

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The GAP between axon pruning and repulsion.

Choe Youngshik Y   Pleasure Samuel J SJ  

Developmental cell 20120701 1

Stereotyped axonal pruning and growth cone repulsion, modulators of neuronal connectivity, share many ligands and receptors systems. Riccomagno et al. (2012) show in Cell that common ligands can link functionally specialized downstream pathways, demonstrating that the Rac GAP β2-Chimaerin is needed in Semaphorin-mediated axonal pruning but not growth cone repulsion. ...[more]

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