Sulfate conjugates are urinary markers of inhalation exposure to 4-chlorobiphenyl (PCB3).
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ABSTRACT:
SUBMITTER: Dhakal K
PROVIDER: S-EPMC3703249 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
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Sulfate conjugates are urinary markers of inhalation exposure to 4-chlorobiphenyl (PCB3).
Dhakal Kiran K Adamcakova-Dodd Andrea A Lehmler Hans-Joachim HJ Thorne Peter S PS Robertson Larry W LW
Chemical research in toxicology 20130528 6
PCBs are contaminants in the air of older buildings and cities, which raises the concern of inhalation exposure. No reliable biomarker of such exposure is available. We exposed rats to air containing 2 mg/m(3) PCB3 via nose-only inhalation for 2 h, collected urine, and analyzed it by LC/MS. Each rat inhaled an estimated dose of 35 μg PCB3, and excreted 27 ± 2% of it as sulfates within 24 h. Peak excretion occurred within 6 h. PCB sulfates were stable in urine for at least three days at room temp ...[more]
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