Ontology highlight
ABSTRACT:
SUBMITTER: Bedoya F
PROVIDER: S-EPMC3703618 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Bedoya Felipe F Cheng Guang-Shing GS Leibow Abigail A Zakhary Nardine N Weissler Katherine K Garcia Victoria V Aitken Malinda M Kropf Elizabeth E Garlick David S DS Wherry E John EJ Erikson Jan J Caton Andrew J AJ
Journal of immunology (Baltimore, Md. : 1950) 20130510 12
We examined the formation, participation, and functional specialization of virus-reactive Foxp3(+) regulatory T cells (Tregs) in a mouse model of influenza virus infection. "Natural" Tregs generated intrathymically, based on interactions with a self-peptide, proliferated in response to a homologous viral Ag in the lungs and, to a lesser extent, in the lung-draining mediastinal lymph nodes (medLNs) of virus-infected mice. In contrast, conventional CD4(+) T cells with identical TCR specificity und ...[more]