Genome-wide analysis of immune system genes by expressed sequence Tag profiling.

ABSTRACT: Profiling studies of mRNA and microRNA, particularly microarray-based studies, have been extensively used to create compendia of genes that are preferentially expressed in the immune system. In some instances, functional studies have been subsequently pursued. Recent efforts such as the Encyclopedia of DNA Elements have demonstrated the benefit of coupling RNA sequencing analysis with information from expressed sequence tags (ESTs) for transcriptomic analysis. However, the full characterization and identification of transcripts that function as modulators of human immune responses remains incomplete. In this study, we demonstrate that an integrated analysis of human ESTs provides a robust platform to identify the immune transcriptome. Beyond recovering a reference set of immune-enriched ge

SUBMITTER: Giallourakis CC 

PROVIDER: S-EPMC3703829 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature