Ontology highlight
ABSTRACT:
SUBMITTER: Bradshaw EM
PROVIDER: S-EPMC3703870 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Nature neuroscience 20130523 7
In our functional dissection of the CD33 Alzheimer's disease susceptibility locus, we found that the rs3865444(C) risk allele was associated with greater cell surface expression of CD33 in the monocytes (t50 = 10.06, P(joint) = 1.3 × 10(-13)) of young and older individuals. It was also associated with diminished internalization of amyloid-β 42 peptide, accumulation of neuritic amyloid pathology and fibrillar amyloid on in vivo imaging, and increased numbers of activated human microglia. ...[more]