Inhibition of soluble epoxide hydrolase by fulvestrant and sulfoxides.
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ABSTRACT:
SUBMITTER: Morisseau C
PROVIDER: S-EPMC3703951 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Publications
Inhibition of soluble epoxide hydrolase by fulvestrant and sulfoxides.
Morisseau Christophe C Pakhomova Svitlana S Hwang Sung Hee SH Newcomer Marcia E ME Hammock Bruce D BD
Bioorganic & medicinal chemistry letters 20130506 13
The soluble epoxide hydrolase (sEH) is a key enzyme in the metabolism of epoxy-fatty acids, signaling molecules involved in numerous biologies. Toward finding novel inhibitors of sEH, a library of known drugs was tested for inhibition of sEH. We found that fulvestrant, an anticancer agent, is a potent (KI=26 nM) competitive inhibitor of sEH. From this observation, we found that alkyl-sulfoxides represent a new kind of pharmacophore for the inhibition of sEH. ...[more]
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Project description:[Figure: see text].
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