Ontology highlight
ABSTRACT:
SUBMITTER: Feng S
PROVIDER: S-EPMC3704010 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Feng Shengjie S Li Hongyu H Tai Yilin Y Huang Junbo J Su Yujuan Y Abramowitz Joel J Zhu Michael X MX Birnbaumer Lutz L Wang Yizheng Y
Proceedings of the National Academy of Sciences of the United States of America 20130617 27
Mitochondrial Ca(2+) homeostasis is fundamental to regulation of mitochondrial membrane potential, ATP production, and cellular Ca(2+) homeostasis. It has been known for decades that isolated mitochondria can take up Ca(2+) from the extramitochondrial solution, but the molecular identity of the Ca(2+) channels involved in this action is largely unknown. Here, we show that a fraction of canonical transient receptor potential 3 (TRPC3) channels is localized to mitochondria, a significant fraction ...[more]